Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor
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چکیده
منابع مشابه
NO signalling in mice lacking the NO receptor guanylyl cyclase
NO-sensitive guanylyl cyclase (NO-GC) is accepted to be the major receptor for the signaling molecule NO. NO-GC catalyzes the production of the intracellular second messenger cGMP and thereby has a key regulatory function regarding various physiological processes. NO-GC is made up of one β subunit and one α subunit. On the protein level, there are two α subunits (α1 and α2) and one β subunit (β...
متن کاملRenal effects of uroguanylin and guanylin in vivo.
Uroguanylin and guanylin are newly discovered endogenous heat-stable peptides that bind to and activate a membrane bound guanylyl cyclase signaling receptor (termed guanylyl cyclase C; GC-C). These peptides are not only found in blood but are secreted into the lumen of the intestine and effect a net secretion of electrolytes (Na+, K+, Cl-, HCO3-) and fluid into the intestine via a cyclic guanos...
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Background The NO/cGMP signal transduction is involved in the regulation of a variety of physiological processes e.g. smooth muscle relaxation, inhibition of platelet aggregation and synaptic plasticity. Nitric oxide (NO) is produced by NO synthases and acts mainly on NOsensitive guanylyl cyclase (NO-GC), the most important NO receptor. NO stimulation of NO-GC leads to production of the second ...
متن کاملGlycosylation of human receptor guanylyl cyclase C
Background Post translational modifications regulate several signalling pathways and glycosylation is emerging as a key player in this regulatory process. Glycosylation of cell surface receptors modulate the downstream signalling pathway and when altered causes a change in the normal physiology of the cell [1]. Guanylyl cyclase C (GC-C) belongs to a group of membrane bound receptors that produc...
متن کاملGuanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue
Guanylyl cyclase C (GC-C) is a member of a family of enzymes that metabolize GTP to cGMP and was first identified as a receptor for heat-stable enterotoxin. Guanylin (GNY) has since been identified as an endogenous ligand for GC-C in the intestine of several mammalian species. The GNY/GC-C system regulates ion transportation and pH in the mucosa. Recently, it was reported that GC-C and GNY are ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2004
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.00375.x